Scientific aspects
ST-901 targets blockade of the NMDA receptor.
Clinical aspects
ST-901 is current in IND enabling studies.
Major depression can be devastating for patients and their loved ones. Episodes of major depression are characterized by depressed mood or loss of interest or pleasure in usual activities that lasts for at least 2 weeks and often much longer. These episodes are accompanied by an array of symptoms including changes in eating or sleeping patterns, fatigue, difficulty concentrating, indecision, thoughts of death or suicide, or feelings of despair. About 20% of the population will experience major depression at some time during their lifetime and major depressive disorder (MDD) is a major public health problem.
While many treatments are available, they are often not effective enough. The National Institute of Mental Health-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D), the most comprehensive and largest clinical study of MDD, showed that remission of depressive symptoms is achieved in only one-third of patients after their first antidepressant treatment trial with an established antidepressant medication and 33% of patients did not reach remission even after treatment with 4 different medications (Rush et al. 2006). Since most antidepressant medications generally take 4- 6 weeks to relieve depression, patients who required multiple medication trials spent months waiting for relief to come.
ST-901 targets blockade of the NMDA receptor.
ST-901 is current in IND enabling studies.
Reid Huber joined Third Rock in 2018 as a Partner, bringing more than 25 years of leadership and experience to the role. He focuses on the formation, development, and strategy of Third Rock’s portfolio companies. Reid served as Interim CEO of MOMA Therapeutics until the appointment of Dr. Asit Parikh in Spring of 2021, of Rapport Therapeutics until the appointment of Abe Ceesay in the Spring of 2023, and of Merida Biosciences until the appointment of Adam Townsend in the Spring of 2025.
Reid joined TRV from Incyte, where he was a member of the founding scientific team and most recently served as executive vice president and chief scientific officer. At Incyte, he held roles of increasing responsibility across multiple therapeutic areas in both drug discovery and clinical development. In 2011, he assumed responsibility for the company’s research and early development activities. Before joining Incyte, Reid held scientific research positions at DuPont Pharmaceuticals and Bristol-Myers Squibb from 1998 to 2002.
He received his Ph.D. in molecular genetics from the Washington University School of Medicine and held predoctoral and postdoctoral fellowships at the National Institutes
of Health.
Reid is a board director at Rapport Therapeutics, Merida Biosciences, Terremoto, Synnovation Therapeutics, MOMA Therapeutics, Asher Biotherapeutics, and a board observer at insitro.
